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Support our research on CMT
Ohio State University has established a Charcot-Marie-Tooth Disease Type 2E Research Fund to support research on the mechanisms and treatment of Charcot-Marie-Tooth disease caused by mutations in neurofilament protein L
MBoC Science Sketch video
Check out the Science Sketch video that accompanies our article on The Role of Neurofilament Transport in the Radial Growth of Myelinated Axons, published in Molecular Biology of the Cell
ABOUT OUR LAB
We are cell biologists in the Department of Neuroscience at Ohio State University. We study the cytoskeleton of nerve cells and the mechanism of axonal transport.
Our main focus is the biology neurofilaments in health and disease. We use a broad range of cellular and molecular techniques to study the transport and assembly dynamics of neurofilaments in nerve cells.
Our core expertise is in light microscopy, protein biochemistry and nerve cell culture.
Recent Publications More
Uchida A, Peng J & Brown A (2023). Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing. Molecular Biology of the Cell 34:ar68, 1–15
PubMed | pdf | movies
Fenn JD, Li Y, Julien J-P, Jung P & Brown A (2023). The mobility of neurofilaments in mature myelinated axons of adult mice. eNeuro 10:ENEURO.0029-23.2023
PubMed | pdf | movies
CONTACT US
Department of Neuroscience
Ohio State University
Rightmire Hall
1060 Carmack Road
Columbus, OH 43210
Office: 614-292-1205
Lab: 614-292-1367
Email: brown.2302@osu.edu