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Support our research on CMT

Ohio State University has established a Charcot-Marie-Tooth Disease Type 2E Research Fund to support research on the mechanisms and treatment of Charcot-Marie-Tooth disease caused by mutations in neurofilament protein L

New neurofilament constructs on Addgene

A panel of our rat and human CMT2E mutant NFL mammalian expression constructs are now available on Addgene

ABOUT OUR LAB

We are cell biologists in the Department of Neuroscience at Ohio State University. We study the cytoskeleton of nerve cells and the mechanism of axonal transport.

Our main focus is the biology neurofilaments in health and disease. We use a broad range of cellular and molecular techniques to study the transport and assembly dynamics of neurofilaments in nerve cells.

Our core expertise is in light microscopy, protein biochemistry and nerve cell culture.

Recent Publications More

    Walker CL, Uchida A, Li Y, Trivedi N, Fenn JD, Monsma PC, Lariviere RC, Julien JP, Jung P & Brown A (2019). Local acceleration of neurofilament transport at nodes of Ranvier. Journal of Neuroscience 39:663-677
    PubMed | pdf


    Ciocanel MV, Jung P & Brown A (2020). A mechanism for neurofilament transport acceleration through nodes of Ranvier. Molecular Biology of the Cell 31:640-654
    PubMed | pdf

CONTACT US

Department of Neuroscience
Ohio State University
Rightmire Hall
1060 Carmack Road
Columbus, OH 43210

Map and directions

Office: 614-292-1205
Lab: 614-292-1367
Email: brown.2302@osu.edu