Featured News More
Support our research on CMT
Ohio State University has established a Charcot-Marie-Tooth Disease Type 2E Research Fund to support research on the mechanisms and treatment of Charcot-Marie-Tooth disease caused by mutations in neurofilament protein L
New neurofilament constructs on Addgene
A panel of our rat and human CMT2E mutant NFL mammalian expression constructs are now available on Addgene
ABOUT OUR LAB
We are cell biologists in the Department of Neuroscience at Ohio State University. We study the cytoskeleton of nerve cells and the mechanism of axonal transport.
Our main focus is the biology neurofilaments in health and disease. We use a broad range of cellular and molecular techniques to study the transport and assembly dynamics of neurofilaments in nerve cells.
Our core expertise is in light microscopy, protein biochemistry and nerve cell culture.
Recent Publications More
Uchida A & Brown A (2021). Regulation of neurofilament length and transport by a dynamic cycle of polymer severing and annealing. bioRxiv 427018
Boyer NP, Julien J-P, Jung P & Brown A (2022). Neurofilament transport is bidirectional in vivo. eNeuro 9:ENEURO.0138-22.2022