Our paper on Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing is one of three papers selected for a talk in the ASCB’s Research Highlights Webinar on Cell Biology of the Nervous System to promote Molecular Biology of the Cell’s special issue on this topic
May 2023Check out the Science Sketch video that accompanies our recent article on The Role of Neurofilament Transport in the Radial Growth of Myelinated Axons, published in Molecular Biology of the Cell
Apr 2023Our paper on The Role of Neurofilament Transport in the Radial Growth of Myelinated Axons was one of three papers selected for a talk in the ASCB’s Research Highlights Webinar on Quantitative Cell Biology to promote Molecular Biology of the Cell’s special issue on this topic. Congratulations to Rawan on a great presentation.
Jun 2022Congratulations to Tori on her matriculation in the Ph.D. Program at the Mayo Clinic Graduate School of Biomedical Sciences
Sep 2021The Brown lab receives NIH funding to explore a gene therapy strategy for Charcot-Marie-Tooth disease in a mouse model of CMT2E, leveraging pilot funding from the Charcot-Marie-Tooth Association
Aug 2020The Brown lab receives funding from the Charcot-Marie-Tooth Association to explore gene therapy strategies for Charcot-Marie-Tooth disease Type 2E
Mar 2020Liz Stone receives her Ph.D. in Neuroscience. Congratulations Liz!
Jan 2020A panel of our rat and human CMT2E mutant NFL mammalian expression constructs are now available on Addgene
Jun 2019Tony has been awarded an S10 Shared Instrument Grant from the National Institutes of Health to purchase a Zeiss Airyscan confocal microscope for the Neuroscience Imaging Core
Jan 2019In Walker et al (2019), we show that neurofilament transport is accelerated locally at nodes of Ranvier, where axons are constricted, and we propose that this acceleration is necessary to ensure a stable axonal morphology across these physiologically important sites
Jan 2019The Brown lab welcomes new post-doc Nick Boyer, who obtained his PhD with Stephanie Gupton at the University of North Carolina at Chapel Hill and is supported by an Ohio State University President’s Post-doctoral Scholars Program fellowship
Sep 2017Tony has been awarded a $1.84 million P30 Center Core grant from the NIH National Institute of Neurological Disorders and Stroke to fund the Ohio State University Neuroscience Center Core which provides core facilities in behavior, injury, electrophysiology and imaging to support neuroscience research across campus
Jan 2017Data from Wang & Brown (2001) featured in the 3rd edition of the textbook “Cell Biology” by Pollard, Earnshaw, Lippincott-Schwartz & Johnson, Saunders Elsevier, 2017 (Fig. 37-5, p. 645)
Nov 2016Our untagged mouse neurofilament protein L, M and H cDNA expression constructs are now available on Addgene
Nov 2016Congratulations to Atsuko on her promotion to Research Scientist
Sep 2016Announcing a special issue of the journal Cytoskeleton on Emerging Concepts of the Cytoskeleton Part I and Part II, edited by PW Baas, JR Bamburg, A Brown & C Gonzalez-Billault
Dec 2015Tony has been appointed Co-Director of the Molecular, Cellular and Developmental Biology graduate program. With approximately 90 students and 140 mentoring faculty, the program is the largest of the interdisciplinary life sciences graduate programs at Ohio State University.
Dec 2015Announcing a Special Interest Subgroup on Neuronal Cytoskeleton: Cytoarchitecture and Dynamics at the 55th Annual Meeting of the American Society for Cell Biology in San Diego, Dec. 11, 2015, co-organized by Anthony Brown (Ohio State), Stephanie Gupton (UNC Chapel Hill), Laura Anne Lowery (Boston College) & Subhojit Roy (UCSD)
Sep 2014Announcing an EMBO Workshop on Emerging Concepts of the Neuronal Cytoskeleton, co-organized by Christian Gonzalez-Billault (University of Chile) and Anthony Brown (Ohio State University), March 22-26, 2015, Puerto Varas, Chile
Aug 2014In Johnson et al (2015), we show using computational modeling that the constriction of axons at nodes of Ranvier in the peripheral nervous system appears to function to increase axonal conduction velocity
Jul 2013Our discovery of neurofilament severing and end-to-end annealing in neurons is featured in an article on MedicalXpress.com
Jun 2013In Uchida et al (2013) we demonstrate severing and end-to-end annealing of neurofilaments in neurons and propose that these are general mechanisms for regulating intermediate filament length
Jan 2013In Brown & Jung (2013) we present a critique of the stationary axonal cytoskeleton hypothesis and propose a dynamic view of the neuronal cytoskeleton in which all neurofilaments cycle repeatedly between moving and pausing states throughout their journey along the axon
Jan 2012 2Li et al (2012) paper in Journal of Neuroscience featured in This Week in the Journal
Jan 2012 1In Li et al (2012) we present a critical reevaluation of neurofilament transport in the mouse optic nerve using computational modeling and we argue that there is no evidence for the deposition of axonal neurofilaments into a long-lived stationary network
Nov 2011Our rat and mouse GFP-tagged neurofilament protein M constructs are now available on Addgene
Oct 2011Our headless and full length mouse kinesin-1 A,B and C constructs are now available on Addgene; see Uchida et al (2009) for more information
Sep 2011Atsuko Uchida receives a 2011 American Society for Cell Biology Post-Doctoral Travel Award to attend the Annual Meeting in Denver, CO
Jan 2011Lina Wang awarded Young Investigator’s Educational Enhancement (YIEE) travel award by the American Society for Neurochemistry to attend the 42nd annual ASN meeting in St. Louis, MO
Dec 2010 2In Wang & Brown (2010) we show that an SPG10 mutation in the motor domain of kinesin-1A/KIF5A disrupts bidirectional neurofilament transport in cultured neurons
Dec 2010 1Special Interest Subgroup on Axonal Transport at the Nexus of Development, Signaling and Disease at the 50th meeting of the American Society for Cell Biology in Philadelphia, co-organized by Anthony Brown and Peter Hollenbeck
Jun 2010Lina Wang receives an Ohio State University Graduate School Alumni Grant for Graduate Research and Scholarship (AGGRS) Award
Dec 2009 4Jung & Brown (2009) paper in Physical Biology featured in the journal’s Highlights of 2009
Dec 2009 3Uchida et al (2009) paper in Molecular Biology of the Cell highlighted in InCytes from MBC
Dec 2009 2Nael Alami receives his Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Nael!
Dec 2009 1Jung & Brown (2009) paper in Physical Biology featured in IOP Select, which is an online collection of articles chosen by the journal editors for their “novelty, significance and potential impact on future research”
Aug 2009 2Gulsen Colakoglu receives her Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Gulsen!
Aug 2009 1Colakoglu & Brown (2009) paper in Journal of Cell Biology featured in the Research Highlights section of Nature Reviews Molecular Cell Biology
Jun 2009 2Colakoglu & Brown (2009) paper in Journal of Cell Biology rated “Must Read” by Faculty of 1000
Jun 2009In Colakoglu & Brown (2009) we demonstrate that intermediate filaments can elongate by end-to-end annealing and that they can exchange subunits along their length by intercalary subunit exchange.
Mar 2009Nael Alami receives an Edward J. Ray Travel Award from the Ohio State University Council of Graduate Students to attend the Keystone Symposium on “Neurodegenerative Diseases: New Molecular Mechanisms” in Keystone, CO
Sept 2008Gulsen Colakoglu receives $25,000 Jeffrey J. Seilhamer Fellowship Award from the Ohio State University Graduate Program in Molecular, Cellular and Developmental Biology. Congratulations Gulsen!
Oct 2007Gulsen Colakoglu receives a 2007 American Society for Cell Biology Travel Award to attend the Annual Meeting in Washington, DC
Jun 2007Data from Wang et al (2000) paper in Nature Cell Biology featured in the textbook “Molecular Cell Biology” (Fig. 20-19, p. 770, Lodish et al., Sixth ed., W.H.Freeman & Co., © 2008)
Apr 2007Data from Wang & Brown (2001) featured in the 2nd edition of the textbook “Cell Biology” by Pollard, Earnshaw & Lippincott-Schwartz, Saunders Elsevier, 2008 (Fig. 37-5, p. 678)
Feb 2007Trivedi et al (2007) paper in Journal of Neuroscience rated “Recommended” by Faculty of 1000
Jun 2006Prof. Keqin Xie, Ph.D. Professor & Director, Institute of Toxicology Institute of Toxicology, School of Public Health, Shandong University, China, is Visiting Scholar in Brown lab, June-December 2006
Dec 2005 2Atsuko Uchida receives the 2005 Molecular Biology of the Cell Paper of the Year Award for her paper published in Molecular Biology of the Cell in 2004
Dec 2005 1Atsuko presents in the “Intermediate Filaments” Minisymposium at the 45th. Annual Meeting of the American Society for Cell Biology in San Francisco, CA
Sept 2005In Brown et al (2005) we demonstrate that the kinetics of slow axonal transport in vivo can be explained by rapid intermittent movements