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March 2020

Liz Stone receives her Ph.D. in Neuroscience. Congratulations Liz!

NIH award to purchase confocal microscope

Tony has been awarded an S10 Shared Instrument Grant from the National Institutes of Health to purchase a Zeiss Airyscan confocal microscope for the Neuroscience Imaging Core

Jan 2019

In Walker et al (2019), we show that neurofilament transport is accelerated locally at nodes of Ranvier, where axons are constricted, and we propose that this acceleration is necessary to ensure a stable axonal morphology across these physiologically important sites

Jan 2019

The Brown lab welcomes new post-doc Nick Boyer, who obtained his PhD with Stephanie Gupton at the University of North Carolina at Chapel Hill and is supported by an Ohio State University President’s Post-doctoral Scholars Program fellowship

Sept 2017

Tony has been awarded a $1.84 million P30 Center Core grant from the NIH National Institute of Neurological Disorders and Stroke to fund the Ohio State University Neuroscience Center Core which provides core facilities in behavior, injury, electrophysiology and imaging to support neuroscience research across campus

Jan 2017

Data from Wang & Brown (2001) featured in the 3rd edition of the textbook “Cell Biology” by Pollard, Earnshaw, Lippincott-Schwartz & Johnson, Saunders Elsevier, 2017 (Fig. 37-5, p. 645)

November 2016

Our untagged mouse neurofilament protein L, M and H cDNA expression constructs are now available on Addgene

Nov 2016

Congratulations to Atsuko on her promotion to Research Scientist

Sep 2016

Announcing a special issue of the journal Cytoskeleton on Emerging Concepts of the Cytoskeleton Part I and Part II, edited by PW Baas, JR Bamburg, A Brown & C Gonzalez-Billault

Dec 2015

Tony has been appointed Co-Director of the Molecular, Cellular and Developmental Biology graduate program. With approximately 90 students and 140 mentoring faculty, the program is the largest of the interdisciplinary life sciences graduate programs at Ohio State University.

Dec 2015

Announcing a Special Interest Subgroup on Neuronal Cytoskeleton: Cytoarchitecture and Dynamics at the 55th Annual Meeting of the American Society for Cell Biology in San Diego, Dec. 11, 2015, co-organized by Anthony Brown (Ohio State), Stephanie Gupton (UNC Chapel Hill), Laura Anne Lowery (Boston College) & Subhojit Roy (UCSD)

Sep 2014

Announcing an EMBO Workshop on Emerging Concepts of the Neuronal Cytoskeleton, co-organized by Christian Gonzalez-Billault (University of Chile) and Anthony Brown (Ohio State University), March 22-26, 2015, Puerto Varas, Chile

Aug 2014

In Johnson et al (2015), we show using computational modeling that the constriction of axons at nodes of Ranvier in the peripheral nervous system appears to function to increase axonal conduction velocity

Jul 2013

Our discovery of neurofilament severing and end-to-end annealing in neurons is featured in an article on MedicalXpress.com

Jun 2013

In Uchida et al (2013) we demonstrate severing and end-to-end annealing of neurofilaments in neurons and propose that these are general mechanisms for regulating intermediate filament length

Jan 2013

In Brown & Jung (2013) we present a critique of the stationary axonal cytoskeleton hypothesis and propose a dynamic view of the neuronal cytoskeleton in which all neurofilaments cycle repeatedly between moving and pausing states throughout their journey along the axon

Jan 2012 2

Li et al (2012) paper in Journal of Neuroscience featured in This Week in the Journal

Jan 2012 1

In Li et al (2012) we present a critical reevaluation of neurofilament transport in the mouse optic nerve using computational modeling and we argue that there is no evidence for the deposition of axonal neurofilaments into a long-lived stationary network

Nov 2011

Our rat and mouse GFP-tagged neurofilament protein M constructs are now available on Addgene

Oct 2011

Our headless and full length mouse kinesin-1 A,B and C constructs are now available on Addgene; see Uchida et al (2009) for more information

Sep 2011

Atsuko Uchida receives a 2011 American Society for Cell Biology Post-Doctoral Travel Award to attend the Annual Meeting in Denver, CO

Jan 2011

Lina Wang awarded Young Investigator’s Educational Enhancement (YIEE) travel award by the American Society for Neurochemistry to attend the 42nd annual ASN meeting in St. Louis, MO

Dec 2010 2

In Wang & Brown (2010) we show that an SPG10 mutation in the motor domain of kinesin-1A/KIF5A disrupts bidirectional neurofilament transport in cultured neurons

Dec 2010 1

Special Interest Subgroup on Axonal Transport at the Nexus of Development, Signaling and Disease at the 50th meeting of the American Society for Cell Biology in Philadelphia, co-organized by Anthony Brown and Peter Hollenbeck

Jun 2010

Lina Wang receives an Ohio State University Graduate School Alumni Grant for Graduate Research and Scholarship (AGGRS) Award

Dec 2009 4

Jung & Brown (2009) paper in Physical Biology featured in the journal’s Highlights of 2009

Dec 2009 3

Uchida et al (2009) paper in Molecular Biology of the Cell highlighted in InCytes from MBC

Dec 2009 2

Nael Alami receives his Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Nael!

Dec 2009 1

Jung & Brown (2009) paper in Physical Biology featured in IOP Select, which is an online collection of articles chosen by the journal editors for their “novelty, significance and potential impact on future research”

Aug 2009 2

Gulsen Colakoglu receives her Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Gulsen!

Aug 2009 1

Colakoglu & Brown (2009) paper in Journal of Cell Biology featured in the Research Highlights section of Nature Reviews Molecular Cell Biology

Jun 2009 2

Colakoglu & Brown (2009) paper in Journal of Cell Biology rated “Must Read” by Faculty of 1000

Jun 2009

In Colakoglu & Brown (2009) we demonstrate that intermediate filaments can elongate by end-to-end annealing and that they can exchange subunits along their length by intercalary subunit exchange.

Mar 2009

Nael Alami receives an Edward J. Ray Travel Award from the Ohio State University Council of Graduate Students to attend the Keystone Symposium on “Neurodegenerative Diseases: New Molecular Mechanisms” in Keystone, CO

Sept 2008

Gulsen Colakoglu receives $25,000 Jeffrey J. Seilhamer Fellowship Award from the Ohio State University Graduate Program in Molecular, Cellular and Developmental Biology. Congratulations Gulsen!

Oct 2007

Gulsen Colakoglu receives a 2007 American Society for Cell Biology Travel Award to attend the Annual Meeting in Washington, DC

Jun 2007

Data from Wang et al (2000) paper in Nature Cell Biology featured in the textbook “Molecular Cell Biology” (Fig. 20-19, p. 770, Lodish et al., Sixth ed., W.H.Freeman & Co., © 2008)

Apr 2007

Data from Wang & Brown (2001) featured in the 2nd edition of the textbook “Cell Biology” by Pollard, Earnshaw & Lippincott-Schwartz, Saunders Elsevier, 2008 (Fig. 37-5, p. 678)

Feb 2007

Trivedi et al (2007) paper in Journal of Neuroscience rated “Recommended” by Faculty of 1000

Jun 2006

Prof. Keqin Xie, Ph.D. Professor & Director, Institute of Toxicology Institute of Toxicology, School of Public Health, Shandong University, China, is Visiting Scholar in Brown lab, June-December 2006

Dec 2005 2

Atsuko Uchida receives the 2005 Molecular Biology of the Cell Paper of the Year Award for her paper published in Molecular Biology of the Cell in 2004

Dec 2005 1

Atsuko presents in the “Intermediate Filaments” Minisymposium at the 45th. Annual Meeting of the American Society for Cell Biology in San Francisco, CA

Sept 2005

In Brown et al (2005) we demonstrate that the kinetics of slow axonal transport in vivo can be explained by rapid intermittent movements