Support our research on CMT
Ohio State University has established a Charcot-Marie-Tooth Disease Type 2E Research Fund to support research on the mechanisms and treatment of Charcot-Marie-Tooth disease caused by mutations in neurofilament protein L
New neurofilament constructs on Addgene
A panel of our rat and human CMT2E mutant NFL mammalian expression constructs are now available on Addgene
The Brown lab receives NIH funding to explore a gene therapy strategy for Charcot-Marie-Tooth disease in a mouse model of CMT2E, leveraging pilot funding from the Charcot-Marie-Tooth Association
The Brown lab receives funding from the Charcot-Marie-Tooth Association to explore gene therapy strategies for Charcot-Marie-Tooth disease Type 2E
Liz Stone receives her Ph.D. in Neuroscience. Congratulations Liz!
Tony has been awarded an S10 Shared Instrument Grant from the National Institutes of Health to purchase a Zeiss Airyscan confocal microscope for the Neuroscience Imaging Core
In Walker et al (2019), we show that neurofilament transport is accelerated locally at nodes of Ranvier, where axons are constricted, and we propose that this acceleration is necessary to ensure a stable axonal morphology across these physiologically important sites
The Brown lab welcomes new post-doc Nick Boyer, who obtained his PhD with Stephanie Gupton at the University of North Carolina at Chapel Hill and is supported by an Ohio State University President’s Post-doctoral Scholars Program fellowship
Tony has been awarded a $1.84 million P30 Center Core grant from the NIH National Institute of Neurological Disorders and Stroke to fund the Ohio State University Neuroscience Center Core which provides core facilities in behavior, injury, electrophysiology and imaging to support neuroscience research across campus
Data from Wang & Brown (2001) featured in the 3rd edition of the textbook “Cell Biology” by Pollard, Earnshaw, Lippincott-Schwartz & Johnson, Saunders Elsevier, 2017 (Fig. 37-5, p. 645)
Our untagged mouse neurofilament protein L, M and H cDNA expression constructs are now available on Addgene
Congratulations to Atsuko on her promotion to Research Scientist
Tony has been appointed Co-Director of the Molecular, Cellular and Developmental Biology graduate program. With approximately 90 students and 140 mentoring faculty, the program is the largest of the interdisciplinary life sciences graduate programs at Ohio State University.
Announcing a Special Interest Subgroup on Neuronal Cytoskeleton: Cytoarchitecture and Dynamics at the 55th Annual Meeting of the American Society for Cell Biology in San Diego, Dec. 11, 2015, co-organized by Anthony Brown (Ohio State), Stephanie Gupton (UNC Chapel Hill), Laura Anne Lowery (Boston College) & Subhojit Roy (UCSD)
Announcing an EMBO Workshop on Emerging Concepts of the Neuronal Cytoskeleton, co-organized by Christian Gonzalez-Billault (University of Chile) and Anthony Brown (Ohio State University), March 22-26, 2015, Puerto Varas, Chile
In Johnson et al (2015), we show using computational modeling that the constriction of axons at nodes of Ranvier in the peripheral nervous system appears to function to increase axonal conduction velocity
Our discovery of neurofilament severing and end-to-end annealing in neurons is featured in an article on MedicalXpress.com
In Uchida et al (2013) we demonstrate severing and end-to-end annealing of neurofilaments in neurons and propose that these are general mechanisms for regulating intermediate filament length
In Brown & Jung (2013) we present a critique of the stationary axonal cytoskeleton hypothesis and propose a dynamic view of the neuronal cytoskeleton in which all neurofilaments cycle repeatedly between moving and pausing states throughout their journey along the axon
In Li et al (2012) we present a critical reevaluation of neurofilament transport in the mouse optic nerve using computational modeling and we argue that there is no evidence for the deposition of axonal neurofilaments into a long-lived stationary network
Our rat and mouse GFP-tagged neurofilament protein M constructs are now available on Addgene
Atsuko Uchida receives a 2011 American Society for Cell Biology Post-Doctoral Travel Award to attend the Annual Meeting in Denver, CO
Lina Wang awarded Young Investigator’s Educational Enhancement (YIEE) travel award by the American Society for Neurochemistry to attend the 42nd annual ASN meeting in St. Louis, MO
In Wang & Brown (2010) we show that an SPG10 mutation in the motor domain of kinesin-1A/KIF5A disrupts bidirectional neurofilament transport in cultured neurons
Special Interest Subgroup on Axonal Transport at the Nexus of Development, Signaling and Disease at the 50th meeting of the American Society for Cell Biology in Philadelphia, co-organized by Anthony Brown and Peter Hollenbeck
Lina Wang receives an Ohio State University Graduate School Alumni Grant for Graduate Research and Scholarship (AGGRS) Award
Jung & Brown (2009) paper in Physical Biology featured in the journal’s Highlights of 2009
Nael Alami receives his Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Nael!
Jung & Brown (2009) paper in Physical Biology featured in IOP Select, which is an online collection of articles chosen by the journal editors for their “novelty, significance and potential impact on future research”
Gulsen Colakoglu receives her Ph.D. in Molecular Cellular and Developmental Biology. Congratulations Gulsen!
In Colakoglu & Brown (2009) we demonstrate that intermediate filaments can elongate by end-to-end annealing and that they can exchange subunits along their length by intercalary subunit exchange.
Nael Alami receives an Edward J. Ray Travel Award from the Ohio State University Council of Graduate Students to attend the Keystone Symposium on “Neurodegenerative Diseases: New Molecular Mechanisms” in Keystone, CO
Gulsen Colakoglu receives $25,000 Jeffrey J. Seilhamer Fellowship Award from the Ohio State University Graduate Program in Molecular, Cellular and Developmental Biology. Congratulations Gulsen!
Gulsen Colakoglu receives a 2007 American Society for Cell Biology Travel Award to attend the Annual Meeting in Washington, DC
Data from Wang et al (2000) paper in Nature Cell Biology featured in the textbook “Molecular Cell Biology” (Fig. 20-19, p. 770, Lodish et al., Sixth ed., W.H.Freeman & Co., © 2008)
Data from Wang & Brown (2001) featured in the 2nd edition of the textbook “Cell Biology” by Pollard, Earnshaw & Lippincott-Schwartz, Saunders Elsevier, 2008 (Fig. 37-5, p. 678)
Prof. Keqin Xie, Ph.D. Professor & Director, Institute of Toxicology Institute of Toxicology, School of Public Health, Shandong University, China, is Visiting Scholar in Brown lab, June-December 2006
Atsuko Uchida receives the 2005 Molecular Biology of the Cell Paper of the Year Award for her paper published in Molecular Biology of the Cell in 2004
Atsuko presents in the “Intermediate Filaments” Minisymposium at the 45th. Annual Meeting of the American Society for Cell Biology in San Francisco, CA
In Brown et al (2005) we demonstrate that the kinetics of slow axonal transport in vivo can be explained by rapid intermittent movements